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ChemicalBook CAS DataBase List FMoc-NH-8(ethylene glycol)-acetic acid

FMoc-NH-8(ethylene glycol)-acetic acid synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: thionyl chloride; triethylamine; dmap / dichloromethane / 0 °C
1.2: 20 °C
2.1: sodium hydride / tetrahydrofuran / 20 °C
2.2: 20 °C
3.1: sodium hydride / tetrahydrofuran / 0 °C
4.1: triphenylphosphine / tetrahydrofuran; water / 20 °C
4.2: 20 °C
5.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 20 °C

References:

Li, Yu;Wang, Xuemeng;Chen, Yongping;Yang, Zhigang;Jiang, Zhong-Xing [Chemical Communications,2019,vol. 55,# 13,p. 1895 - 1898]

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