FURAN-2-AMIDOXIME synthesis
- Product Name:FURAN-2-AMIDOXIME
- CAS Number:50892-99-4
- Molecular formula:C5H6N2O2
- Molecular Weight:126.1133
617-90-3
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Yield:50892-99-4 99%
Reaction Conditions:
with hydroxylamine monohydrate in ethanol at 90; for 1.5 h;Sealed tube;
Steps:
4.1.4. General procedure for the synthesis of amidoximes (39e52)
General procedure: In a pressurized sealed vial, aqueous hydroxylamine 50% w/w (4equiv) was added to a stirred solution of the appropriate carbonitrile(1 equiv) in absolute ethanol. The resulting mixture washeated at 90 C for 1 h. The solvent was then evaporated to drynessproviding the desired amidoxime quantitatively, which was usedwithout further purification.
References:
Quadri, Marta;Silnovi?, Almin;Matera, Carlo;Horenstein, Nicole A.;Stokes, Clare;De Amici, Marco;Papke, Roger L.;Dallanoce, Clelia [European Journal of Medicinal Chemistry,2018,vol. 160,p. 207 - 228]