furan-2-yl-(4-methylsulfanylphenyl)methanol synthesis
1synthesis methods
- Product Name:furan-2-yl-(4-methylsulfanylphenyl)methanol
- CAS Number:944697-88-5
- Molecular formula:C12H12O2S
- Molecular Weight:220.2875
Yield:944697-88-5 92%
Reaction Conditions:
Stage #1: (4-bromophenyl)thioanisolewith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;Inert atmosphere;
Stage #2: furfural in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;
References:
Harrak, Youssef;Casula, Giovanni;Basset, Joan;Rosell, Glòria;Plescia, Salvatore;Raffa, Demetrio;Cusimano, Maria Grazia;Pouplana, Ramon;Pujol, Maria Dolors [Journal of Medicinal Chemistry,2010,vol. 53,# 18,p. 6560 - 6571] Location in patent:supporting information; experimental part