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603302-86-9

Furo[3,2-c]pyridine-7-carboxylic acid synthesis

2synthesis methods
603302-76-7 Synthesis
Furo[3,2-c]pyridine-7-carbonitrile (9CI)

603302-76-7
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Furo[3,2-c]pyridine-7-carboxylic acid

603302-86-9
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Yield:-

Reaction Conditions:

with ammonia;water at 150; for 18 h;high pressure reactor;

Steps:

86

Furof3, 2-clpyridine-7-carboxylic acid; Add furo [3,2-c] pyridine-7-carbonitrile (1.5 g, 10.4 mmol) and 28-30% aqueous ammonium hydroxide (50 mL) to high pressure reactor. Heating at 150 °C for 18 hours, cooling to room temperature and freeze-drying gives the title compound as a white solid. ESMS: (m/z) = 164. 0 (M++1).

References:

WO2003/76442,2003,A1 Location in patent:Page/Page column 48