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gossypolone synthesis

3synthesis methods
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Yield:4547-72-2 91%

Reaction Conditions:

Stage #1: (rac)-gossypolwith iron(III) chloride;acetic acid in water;acetone at 100; for 2 h;
Stage #2: with sulfuric acid in diethyl ether;water;

References:

Dodou, Kalliopi;Anderson, Rosaleen J.;Lough, W. John;Small, David A. P.;Shelley, Michael D.;Groundwater, Paul W. [Bioorganic and Medicinal Chemistry,2005,vol. 13,# 13,p. 4228 - 4237]

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