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ChemicalBook CAS DataBase List Imazameth
104098-48-8

Imazameth synthesis

2synthesis methods
Imazapic is synthesised through a multi-step chemical process involving the construction of its imidazolinone core and pyridinecarboxylic acid side chain. The production typically begins with the formation of the imidazolinone ring, which is achieved by cyclising precursors such as methyl isobutyrate and urea derivatives under controlled conditions. This intermediate is then coupled with a methyl-substituted pyridine compound through a condensation or acylation reaction to yield the final active ingredient.
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: sodium hydroxide / isopropyl alcohol / 2.5 h / 70 °C
2: α-picoline; acetic anhydride / toluene / 8 h / 90 °C
3: 20 °C / pH 2
4: dihydrogen peroxide

References:

Shenyang Kechuang Chemicals Co., Ltd.;Cheng Chunsheng;Lin Yang;Yang Zhaoguo;Wang Yongfeng;Meng Xianmei;Ma Xiaohua;Li Ziliang;Zhang Chuanyang CN109467548, 2019, A

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