IMidazo[1,2-a]pyridine-2-Methanol, 7-broMo- synthesis
- Product Name:IMidazo[1,2-a]pyridine-2-Methanol, 7-broMo-
- CAS Number:1187236-21-0
- Molecular formula:C8H7BrN2O
- Molecular Weight:227.06
![IMidazo[1,2-a]pyridine-2-carboxylic acid, 7-broMo-, ethyl ester](/CAS/GIF/1187236-18-5.gif)
1187236-18-5
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Yield:1187236-21-0 52%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at -30;
Steps:
42.2 Step-2: Preparation of (7-bromoimidazo[l,2-a]pyridin-2-yl)methanol.
L1AIH4 (21.26 mL, 21.26 mmol, 1M in THF) was added to a solution of ethyl 7-bromoimidazo[l,2-a]pyridine-2-carboxylate (5.2 g, 19.33 mmol) in THF (100 mL) at -30°C. The reaction was quenched with ethyl acetate (2 X 200 mL) and washed with brine (100 mL). The organic layers were filtered through celite, and the filtrate was concentrated. The crude product was purified using flash chromatography, eluting with 2.8% MeOH:DCM, to give (7-bromoimidazo[l,2- a]pyridin-2-yl)methanol (2.0 g, 52%).LCMS (Method-H): 98.80% (RT 1.947, 230.0 nm) (MS: ESI +ve 228.9 [M+l]).
References:
WO2021/242923,2021,A1 Location in patent:Paragraph 01039-001040
84249-14-9
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