Indole-3-amidoxime synthesis
- Product Name:Indole-3-amidoxime
- CAS Number:95649-37-9
- Molecular formula:C9H9N3O
- Molecular Weight:175.19
5457-28-3
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$10.00/1g
95649-37-9
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$79.00/250mg
Yield:95649-37-9 99%
Reaction Conditions:
with hydroxylamine hydrochloride;triethylamine in ethanol at 80; for 12 h;
Steps:
2.a General Procedure 1:
Amidoxime Formation Cyano indole la-d ( 1 equiv.) and hydroxylamine hydrochloride (3 equiv.), and TEA (3 equiv.) were added to a round bottom flask containing ethanol. The reaction mixture was heated to 80 °C for 12 hours or until the reaction appeared to have gone to completion via monitoring by TLC. The solution was cooled to room temperature and the solvent was removed under reduced pressure. The resulting solid was loaded onto celite and purified on a silica gel column with 0-10% methanol in ethyl acetate.
References:
WO2016/54261,2016,A1 Location in patent:Page/Page column 63; 64; 66
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5457-28-3
308 suppliers
$10.00/1g
95649-37-9
20 suppliers
$79.00/250mg
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5457-28-3
308 suppliers
$10.00/1g
95649-37-9
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$79.00/250mg
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95649-37-9
20 suppliers
$79.00/250mg