isopropanyl 2,4-dichloropyriMidine-5-carboxylate synthesis
- Product Name:isopropanyl 2,4-dichloropyriMidine-5-carboxylate
- CAS Number:69312-43-2
- Molecular formula:C8H8Cl2N2O2
- Molecular Weight:235.07
67-63-0
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Yield: 81%
Reaction Conditions:
in tetrahydrofuran at 20;Cooling with ice;
Steps:
1.B Step B: 2,4-Dichloropyrimidine-5-carboxylic acid isopropyl ester
21 g (100 mmol, 1.0 eq) of 2,4-dichloropyrimidine-5-formyl chloride was dissolved in 150 mL of anhydrous tetrahydrofuran, and 13.2 g (110 mmol, 2.2 eq) of isopropanol was slowly added dropwise under an ice bath,After the addition, the reaction system was warmed to room temperature overnight.The solvent was evaporated to dryness under reduced pressure, and the residue was purified by silica gel column chromatography to obtain the product (18.3 g, yield = 81%).
References:
Beijing Puqi Pharmaceutical Technology Co., Ltd.;Zhu Li;Hu Wei;Wu Wei;Yang Yanqing;Zhang Hui CN110790749, 2020, A Location in patent:Paragraph 0098; 0103-0106
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