Lipstatin synthesis
- Product Name:Lipstatin
- CAS Number:96829-59-3
- Molecular formula:C29H49NO5
- Molecular Weight:491.7
66-25-1
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Yield:-
Steps:
Multi-step reaction with 11 steps
1: 100 percent / NaN(SiMe3)2 / tetrahydrofuran / 12 h / -100 deg C to RT
2: p-TsOH / H2O; tetrahydrofuran / 0.17 h / Heating
3: LiAlH4 / tetrahydrofuran / 2.5 h / -90 to -20 deg C
4: 90 percent / PPh3Br2, pyridine / acetonitrile / 1 h / -7 to RT
5: 100 percent / acetonitrile / 48 h / Heating
6: 86 percent / NaN(SiMe3)2 / tetrahydrofuran / 12 h / -100 deg C to RT
7: 93 percent / DIBAH / CH2Cl2 / 1 h / -90 °C
8: 81 percent / EtAlCl2 / diethyl ether; hexane / 2.5 h / -40 to -20 deg C
9: 77 percent / 40percent aq. HF / acetonitrile / 12 h / 0 deg C to RT
10: 70 percent / Bu4NF / tetrahydrofuran / 0.25 h / -90 °C
11: 50 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 deg C to RT
References:
Pons, Jean-Marc;Pommier, Agnes;Lerpiniere, Joan;Kocienski, Philip [Journal of the Chemical Society. Perkin transactions I,1993,# 14,p. 1549 - 1552]
10340-23-5
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$32.79/5g
96829-59-3
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31823-43-5
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120018-49-7
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![5,8-Tetradecadienal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R,5Z,8Z)-](/CAS/20210305/GIF/151509-74-9.gif)
151509-74-9
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96829-59-3
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