Maytansinol synthesis
- Product Name:Maytansinol
- CAS Number:57103-68-1
- Molecular formula:C28H37ClN2O8
- Molecular Weight:565.05
![Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-4,5-deepoxy-4,5-didehydro-, (4E)- (9CI)](/CAS/20240320/GIF/75340-67-9.gif)
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
2: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
3: hydrolysis
References:
Corey;Weigel;Chamberlin;et al. [Journal of the American Chemical Society,1980,vol. 102,# 21,p. 6613 - 6615]
![Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-4,5-deepoxy-4,5-didehydro-9-O-methyl-, (4E)- (9CI)](/CAS/20240320/GIF/75349-70-1.gif)
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57103-68-1
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![Spiro[2-azabicyclo[16.3.1]docosa-1(22),6,13,15,18,20-hexaene-11,2'-[1,3]dithian]-3-one, 21-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-hydroxy-12,20-dimethoxy-2,6,8,16-tetramethyl-, [5S-(5R*,6E,8R*,9R*,12S*,13E,15E)]- (9CI)](/CAS/20210111/GIF/75340-66-8.gif)
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57103-68-1
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![Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-4,5-deepoxy-4,5-didehydro-3-O-[(1,1-dimethylethyl)dimethylsilyl]-, (4E)- (9CI)](/CAS/20240320/GIF/75349-69-8.gif)
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57103-68-1
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![Spiro[2-azabicyclo[16.3.1]docosa-1(22),6,13,15,18,20-hexaene-11,2'-[1,3]dithian]-3-one, 9-[(aminocarbonyl)oxy]-21-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-12,20-dimethoxy-2,6,8,16-tetramethyl-, [5S-(5R*,6E,8R*,9R*,12S*,13E,15E)]- (9CI)](/CAS/20210305/GIF/75349-68-7.gif)
75349-68-7
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57103-68-1
191 suppliers
$50.00/5mg