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ChemicalBook CAS DataBase List ME 1207E

ME 1207E synthesis

9synthesis methods
82294-70-0 Synthesis
4-Methylthiazole-5-carboxaldehyde

82294-70-0
282 suppliers
$6.00/1g

-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: NaHCO3 / CH2Cl2; H2O / 17 h / Ambient temperature
2: 1) POCl3, pyridine, 2) MeOH / 1) CH2Cl2, 0-5 deg C, 2 h, 2) 0-5 deg C, 1 h
3: POCl3, pyridine / CH2Cl2 / 2 h / -20 - -10 °C
4: CF3CO2H, anisole / 1 h / 0 °C
5: dimethylformamide / 1 h / -20 °C

References:

Sakagami;Atsumi;Yamamoto;Tamura;Yoshida;Nishihata;Fukatsu [Chemical and Pharmaceutical Bulletin,1991,vol. 39,# 9,p. 2433 - 2436]