methyl 1-isopropyl-1H-indole-6-carboxylate synthesis
2synthesis methods
- Product Name:methyl 1-isopropyl-1H-indole-6-carboxylate
- CAS Number:202745-76-4
- Molecular formula:C13H15NO2
- Molecular Weight:217.26
Yield:202745-76-4 64.5%
Reaction Conditions:
Stage #1: indole-6-carboxylic acid methyl esterwith sodium hydride in N,N-dimethyl-formamide at 20; for 1 h;Metallation;
Stage #2: 2-iodo-propane in N,N-dimethyl-formamide at 80; for 5 h;Alkylation;
References:
Kitano, Masafumi;Kojima, Atsuyuki;Nakano, Kazuhiro;Miyagishi, Akira;Noguchi, Tsuyoshi;Ohashi, Naohito [Chemical and Pharmaceutical Bulletin,1999,vol. 47,# 11,p. 1538 - 1548]