Methyl 2-(3-hydroxyphenyl)-2-Methylpropanoate synthesis
- Product Name:Methyl 2-(3-hydroxyphenyl)-2-Methylpropanoate
- CAS Number:149490-75-5
- Molecular formula:C11H14O3
- Molecular Weight:194.23
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Yield:149490-75-5 92%
Reaction Conditions:
with hydrogen;5%-palladium/activated carbon in ethanol at 20;
Steps:
Reference Example 88
Reference Example 88 A mixture of methyl 2- (3-benzyloxyphenyl)-2- methylpropanoate (19.62 g), 5% palladium-carbon (2. 0 g) and ethanol (100 ml) was stirred overnight at room temperature under a hydrogen atmosphere. Palladium-carbon was removed by filtration and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and methyl 2- (3-hydroxyphenyl) -2-methylpropanoate (12.32 g, yield 92%) was obtained as a pale-yellow oily substance from a fraction eluted with ethyl acetate-hexane (1: 3, volume ratio). H-NMR (CDC13) 6 : 1. 56 (6H, s), 3. 66 (3H, s), 5. 35 (1H, s), 6. 72 (1H, ddd, J=8.1, 2.4, 1.0 Hz), 6.83 (1H, t, J=2.1 Hz), 6.89 (1H, ddd, J=7.8, 1.7, 1.0 Hz), 7.19 (1H, t, J=7.9 Hz)
References:
WO2003/99793,2003,A1 Location in patent:Page 159
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