Methyl 2,6-dichloro-4-cyanobenzoate synthesis
- Product Name:Methyl 2,6-dichloro-4-cyanobenzoate
- CAS Number:409127-32-8
- Molecular formula:C9H5Cl2NO2
- Molecular Weight:230.05
409127-31-7
409127-32-8
Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoate Methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) was dissolved in pyridine (2 mL) and trifluoroacetic anhydride (0.11 mL, 0.8 mmol) was added slowly and dropwise at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was poured into pre-cooled ice water, the precipitated solid was filtered, washed thoroughly with cold water and dried to afford methyl 2,6-dichloro-4-cyanobenzoate (55 mg, 88% yield) as an off-white solid.
409127-31-7
5 suppliers
inquiry
409127-32-8
57 suppliers
inquiry
Yield:409127-32-8 88%
Reaction Conditions:
with pyridine;trifluoroacetic anhydride at 0 - 20; for 1 h;
Steps:
Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoateTo a solution of methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) in pyridine (2 mL) trifluoro-acetic anhydride (0.1 1 ml, 0.8 mmol) was added drop wise at 0 °C. The reaction mixture was allowed to warm to room temperature and stirred for 1 hour. The contents were poured into ice cold water and the precipitated solid was filtered, washed with water and dried to yield methyl 2,6-dichloro-4- cyanobenzoate (55 mg, 88%) as an off-white solid.
References:
WO2012/160464,2012,A1 Location in patent:Page/Page column 77-78
5372-81-6
233 suppliers
$17.67/5gm:
409127-32-8
57 suppliers
inquiry
1258298-04-2
10 suppliers
inquiry
409127-32-8
57 suppliers
inquiry
264276-14-4
37 suppliers
inquiry
409127-32-8
57 suppliers
inquiry
264272-64-2
21 suppliers
inquiry
409127-32-8
57 suppliers
inquiry