Methyl 2,6-dichloro-4-fluorobenzoate synthesis

4synthesis methods

Product Name:Methyl 2,6-dichloro-4-fluorobenzoate
CAS Number:232275-56-8
Molecular formula:C8H5Cl2FO2
Molecular Weight:223.03

232275-49-9
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232275-56-8
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Yield:232275-56-8 48%

Reaction Conditions:

Stage #1: methyl 4-amino-2,6-dichlorobenzoatewith hydrogenchloride;sodium nitrite in water at 0 - 5; for 0.5 h;
Stage #2: with tetrafluoroboric acid in water; for 0.5 h;

References:

Sircar, Ila;Gudmundsson, Kristjan S.;Martin, Richard;Liang, Jimmy;Nomura, Sumihiro;Jayakumar, Honnappa;Teegarden, Bradley R.;Nowlin, Dawn M.;Cardarelli, Pina M.;Mah, Jason R.;Connell, Samuel;Griffith, Ronald C.;Lazarides, Elias [Bioorganic and Medicinal Chemistry,2002,vol. 10,# 6,p. 2051 - 2066]

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232275-56-8
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References

232275-50-2 Synthesis

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References

88135-16-4
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References