METHYL-2-BROMO-4-BROMOMETHYLBENZOATE synthesis
- Product Name:METHYL-2-BROMO-4-BROMOMETHYLBENZOATE
- CAS Number:128577-48-0
- Molecular formula:C9H8Br2O2
- Molecular Weight:307.97
87808-49-9
128577-48-0
General procedure for the synthesis of methyl 2-bromo-4-bromomethylbenzoate from methyl 2-bromo-4-methylbenzoate: the reaction mixture was placed in a controlled microwave synthesizer of the model Biotage Initiator + SP Wave (power range 0-200 W, frequency 2.45 GHz, 60 W capped at steady state) and heated to 120 °C at 1 bar pressure for for several minutes. Upon completion of the reaction, the target product was isolated and purified by column chromatography using ethyl acetate-hexane gradient elution.
87808-49-9
119 suppliers
$8.00/1g
128577-48-0
120 suppliers
$11.00/100mg
Yield: 94%
Reaction Conditions:
with tert.-butylhydroperoxide;cetyltrimethylammonim bromide;potassium bromide in water at 120; under 750.075 Torr;Microwave irradiation;
Steps:
General procedure: The reaction mixture was treated in a controlled microwavesynthesizer (Biotage Initiator+SP Wave model, 0-200 W at2.45 GHz, capped at 60 W during steady state) for severalminutes (the reaction attained 120 °C at 1 bar pressure). Thefinal products were isolated by column chromatographyusing an EtOAc-hexane gradient
References:
Reddy, Kancharla Rajendar;Rajanna, Kamatala C.;Venkateswarlu, Marri;Saiprakash [Synlett,2014,vol. 25,# 17,art. no. ST-2014-D0547-L,p. 2485 - 2487]
7697-27-0
211 suppliers
$6.00/1g
128577-48-0
120 suppliers
$11.00/100mg