methyl 3-(2-piperidinyl)propanoate hydrochloride synthesis
- Product Name:methyl 3-(2-piperidinyl)propanoate hydrochloride
- CAS Number:1021204-94-3
- Molecular formula:C9H18ClNO2
- Molecular Weight:207.7
50610-14-5
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Yield:1021204-94-3 99%
Reaction Conditions:
with hydrogen;platinum(IV) oxide in tetrahydrofuran;chloroform; under 6000.6 Torr;Inert atmosphere;
Steps:
5.2; 2
Methyl 3-(pyridin-2-yl)acrylate (22.15 g, 136 mmol) was dissolved in THF (300 ml) and chloroform (10.9 ml), and PtO2 (3.08 g, 13.6 mmol, 0.1 eq.) was added under a nitrogen atmosphere. The solution was first flushed with nitrogen for 10 min and then stirred under an H2 atmosphere (8 bar) overnight. After cooling, the mixture was first flushed again with nitrogen, the catalyst was removed by filtering over filtering earth and rinsed with MC and the filtrate was concentrated to dryness in vacuo. The methyl 3-(piperidin-2-yl)propionate hydrochloride was employed in the next stage without further purification. Yield: 27.95 g, 99%.
References:
US2009/253669,2009,A1 Location in patent:Page/Page column 45
81124-45-0
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1021204-94-3
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