Methyl 3,5-dimethoxybenzoylformate synthesis
- Product Name:Methyl 3,5-dimethoxybenzoylformate
- CAS Number:1228308-11-9
- Molecular formula:C11H12O5
- Molecular Weight:224.21
553-90-2
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20469-65-2
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1228308-11-9
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$437.00/1g
Yield:1228308-11-9 80%
Reaction Conditions:
Stage #1: 1-bromo-3,5-dimethoxybenzenewith magnesium in tetrahydrofuran;Inert atmosphere;
Stage #2: Dimethyl oxalate in tetrahydrofuran at -78; for 0.5 h;Inert atmosphere;Grignard reaction;
References:
Nicolaou;Kang, Qiang;Wu, T. Robert;Lim, Chek Shik;Chen, David Y.-K. [Journal of the American Chemical Society,2010,vol. 132,# 21,p. 7540 - 7548] Location in patent:supporting information; experimental part