Methyl 3-cyano-4-Methylbenzoate synthesis
- Product Name:Methyl 3-cyano-4-Methylbenzoate
- CAS Number:35066-32-1
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
Yield:35066-32-1 78%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide at 80; for 5 h;Inert atmosphere;
Steps:
General procedure for thesynthesis of Cyanide 3
General procedure: Iodides 2 (10.0 mmol), zinccyanide (10.0 mmol), tetrakis (triphenylphosphine) palladium (2.0 mmol) weredissolved in 20 mL DMF. The reaction was heated at 80 oC for 5 hoursunder the protection of N2. The mixture was extracted with CH2Cl2 (25×3 mL) andorganic layers were combined, washed with brine, dried over Na2SO4.The solvent was evaporated under vacuum to give crude product, which waspurified by column chromatography on silica gel to give products 3-1~3-3.
References:
Han, Mei;Li, Shan;Ai, Jing;Sheng, Rong;Hu, Yongzhou;Hu, Youhong;Geng, Meiyu [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 23,p. 5679 - 5684] Location in patent:supporting information
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