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Methyl 3-Fluoro-4-Morpholinobenzoate synthesis

2synthesis methods
-

Yield:495405-04-4 81%

Reaction Conditions:

in dimethyl sulfoxide at 95; for 20 h;

References:

Barbachyn, Michael R.;Cleek, Gary J.;Dolak, Lester A.;Garmon, Stuart A.;Morris, Joel;Seest, Eric P.;Thomas, Richard C.;Toops, Dana S.;Watt, William;Wishka, Donn G.;Ford, Charles W.;Zurenko, Gary E.;Hamel, Judith C.;Schaadt, Ronda D.;Stapert, Douglas;Yagi, Betty H.;Adams, Wade J.;Friis, Janice M.;Slatter, J. Gregory;Sams, James P.;Oien, Nancee L.;Zaya, Matthew J.;Wienkers, Larry C.;Wynalda, Michael A. [Journal of Medicinal Chemistry,2003,vol. 46,# 2,p. 284 - 302]