Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List methyl 3-formyl-1-methyl-1H-indole-2-carboxylate
88129-40-2

methyl 3-formyl-1-methyl-1H-indole-2-carboxylate synthesis

4synthesis methods
-

Yield:88129-40-2 91%

Reaction Conditions:

Stage #1: methyl 3-formyl-1H-indole-2-carboxylatewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 20; for 1 h;Inert atmosphere;Vilsmeier-Haack Formylation;
Stage #2: methyl iodide in N,N-dimethyl-formamide;mineral oil at 20; for 4 h;Inert atmosphere;

References:

Preti, Delia;Romagnoli, Romeo;Rondanin, Riccardo;Cacciari, Barbara;Hamel, Ernest;Balzarini, Jan;Liekens, Sandra;Schols, Dominique;Estévez-Sarmiento, Francisco;Quintana, José;Estévez, Francisco [Journal of Enzyme Inhibition and Medicinal Chemistry,2018,vol. 33,# 1,p. 1225 - 1238]