METHYL 3-FORMYL-6-METHOXY-1H-INDOLE-2-CARBOXYLATE synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sulfuric acid / 24 h / Reflux; Inert atmosphere
2.1: trichlorophosphate / 0.17 h / 0 °C / Inert atmosphere
2.2: 4.67 h / 0 - 60 °C / Inert atmosphere
2.3: pH 8 / Cooling; Inert atmosphere

References:

Preti, Delia;Romagnoli, Romeo;Rondanin, Riccardo;Cacciari, Barbara;Hamel, Ernest;Balzarini, Jan;Liekens, Sandra;Schols, Dominique;Estévez-Sarmiento, Francisco;Quintana, José;Estévez, Francisco [Journal of Enzyme Inhibition and Medicinal Chemistry,2018,vol. 33,# 1,p. 1225 - 1238]