methyl 4-bromo-2-methoxy-6-methylbenzoate synthesis
- Product Name:methyl 4-bromo-2-methoxy-6-methylbenzoate
- CAS Number:877149-09-2
- Molecular formula:C10H11BrO3
- Molecular Weight:259.1
877149-08-1
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74-88-4
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Yield:877149-09-2 63.97 %
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20;
Steps:
5 Step 5
To a solution of 4-bromo-2-methoxy-6-methyl-benzoic acid (1.73 g, 7.06 mmol, 1 eq) in DMF (20 mL) was added MeI (2.00 g, 14.12 mmol, 878.92 uL, 2 eq) and K2CO3 (2.93 g, 21.18 mmol, 3 eq). The mixture was stirred at 20°C for 1 hr. TLC showed the reaction was completed. The residue was poured into water (20 mL). The aqueous phase was extracted with ethyl acetate (20 mL * 3). The combined organic phase was washed with brine (20 mL * 2), dried with anhydrous Na2SO4, filtered and concentrated in vacuum to give methyl 4-bromo-2-methoxy-6-methyl- benzoate (1.17 g, 4.52 mmol, 63.97% yield) as a white solid.
References:
WO2022/198112,2022,A1 Location in patent:Paragraph 00433
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50868-73-0
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348169-39-1
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