methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate synthesis
- Product Name:methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate
- CAS Number:92406-53-6
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
796038-07-8
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92406-53-6
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Yield: 87%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; under 760.051 Torr; for 4 h;
Steps:
P35.2 Step 2. Synthesis of methyl 5-amino-1-methyl-1H-pyrazol-3-carboxylate (60)
At room temperature, Compound 59 (200 mg, 1.081 mmol) was dissolved in methanol (10 mL) and added with Pd/C (10%, 90 mg). The reaction was stirred for 4 h under 1 atm of hydrogen gas. After the reaction was completed as monitored by LCMS, the reaction was filtered with suction. The filtrate was concentrated under reduced pressure to give methyl 5-amino-1-methyl-1H-pyrazol-3-carboxylate 60 (145 mg, light yellow oil). Yield: 87.0%. LCMS: m/z 156 (M+H).
References:
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;LI, Lei;GENG, Meiyu;HUANG, Ying;DING, Jian;ZHANG, Qiong;HUANG, Min;TANG, Shuai;SHEN, Ning;CHEN, Yi US2020/247781, 2020, A1 Location in patent:Paragraph 0426-0427
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89088-56-2
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92406-53-6
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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92406-53-6
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92406-53-6
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33146-99-5
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92406-53-6
65 suppliers
$85.00/100mg