methyl 6-bromo-5-hydroxypyrazine-2-carboxylate synthesis
- Product Name:methyl 6-bromo-5-hydroxypyrazine-2-carboxylate
- CAS Number:1017603-85-8
- Molecular formula:C6H5BrN2O3
- Molecular Weight:233.0195
13924-95-3
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Yield:1017603-85-8 195 g
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 20; for 16 h;
Steps:
1.B STEP B: methyl 6-bromo-5-hydroxypyrazine-2-carboxylate
To a solution of methyl 5-hydroxypyrazine-2-carboxylate (114 g, 739.67 mmol) in DMF (1.1 L) was added NBS (138.23 g, 776.65 mmol) portion-wise at 0°C. The mixture was stirred at 20°C for 16 hours and was then diluted with water (1 L) and extracted with EtOAc (1 L x 6). The combined organic layers were washed with brine (500 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give the title compound as a red gum (195 g, contains 36% DMF).1H NMR (400 MHz, CD3OD) δ ppm 3.89 (s, 3 H), 8.17 (s, 1 H).
References:
WO2021/202775,2021,A1 Location in patent:Paragraph 0182; 0185-0186
34604-60-9
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