Methyll-bromo-cyclopropanecarboxylate synthesis

Yield:96999-01-8 94%

Reaction Conditions:

with sodium hydride in propylene glycol at 100; for 0.5 h;

Steps:

4
At 20 °C, 78 g (1 mol) of 1,2-propanediol was successively added to the reactor and 4.8 g (0.12 mol) of sodium hydride in an amount of 60% (w%). Then heated to 100 °C, A solution of 26 g (0.1 mol) 2,4-dibromo-butyric acid methyl ester, after dripping, continue to respond for 30 min, after the reaction solution was cooled to room temperature, extracted twice with dichloromethane, the extract was dried over anhydrous sodium sulfate, evaporated to dryness to give 17.5 g of a light yellow transparent liquid, NMR analysis confirmed that 1-(1-bromocyclopropyl)formic acid methyl ester, Yield 94%, purity 96%. 1 H NMR (CDCl 3, 500 MHz, δ / ppm): 3.76 (s, 3H), 1.66-1.69 (m, 2H), 1.38-1.41 (m, 2H).

References:

XI'AN MODERN CHEMISTRY RESEARCH INSTITUTE;LI, BINGBO;WANG, ANYONG;WANG, WEI;LIN, SHUANGZHENG;NING, BINKE;WEI, TIANQI;QIAN, YISHI CN106278890, 2017, A Location in patent:Paragraph 0018-0019

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