MFCD00666862 synthesis

Yield:14348-64-2 47.6%

Reaction Conditions:

with iron(III) chloride hexahydrate in methanol;water at 20; for 4 h;

Steps:

2

Add 4-(2-methylprop-1-en-1-yl)morpholine (7.4g, 52.5mmol) into a 500mL three-necked flask, 1,4-Naphthoquinone (8.3g, 52.5mmol) 75% methanol aqueous solution (300mL) and ferric chloride hexahydrate (16.5g, 61mmol), stirred at room temperature for 4h, the solvent was evaporated to obtain the crude product, washed with water, anhydrous sulfuric acid The sodium was dried, concentrated, and passed through a silica gel column (ethyl acetate/petroleum ether = 1/1001/20) to obtain 2-(1,4-dioxo-1,4-dihydronaphthalen-2-yl) )-2-Methylpropanal (5.7g, yield: 47.6%).

References:

CN112321486,2021,A Location in patent:Paragraph 0033-0036