MK-5046 synthesis
- Product Name:MK-5046
- CAS Number:1022152-70-0
- Molecular formula:C20H18F6N4O
- Molecular Weight:444.38
![1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αR)-](/CAS/20210305/GIF/1021736-25-3.gif)
Yield:-
Reaction Conditions:
with ChiralCel AD-H in n-heptane;isopropyl alcoholResolution of racemate;
Steps:
31
Individual enantiomers (E1 and E2) were obtained by HPLC separation of 1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol (as prepared in Example 30) on a chiral column (ChiralCel AD-H) eluting with IPA/heptane to afford the title compounds. 1H NMR (500 MHz, CD3OD) δ 8.24 (d, J=2.5 Hz, 1H), 7.79 (d, J=8.9 Hz, 2H), 7.73 (s, 1H), 7.64 (d, J=8.7 Hz, 2H), 6.53 (s, 1H), 3.73 (s, 2H), 3.00 (d, J=16 Hz, 1H), 2.92 (d, J=16, 1H), 0.93 (s, 2H), 0.69-0.61 (m, 2H). (M+H) found 445.
References:
Chen, David;Franklin, Christopher L.;Guzzo, Peter R.;Lin, Linus S.;Lo, Michael M.C.;Nargund, Ravi P.;Sebhat, Iyassu K. US2010/22598, 2010, A1 Location in patent:Page/Page column 48-49
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