MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE synthesis
- Product Name:MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE
- CAS Number:91641-50-8
- Molecular formula:C12H16ClNO3
- Molecular Weight:257.7133
22083-23-4
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Yield:91641-50-8 63.7%
Reaction Conditions:
with hydrogenchloride;water in 1,4-dioxane;Reflux;
Steps:
12 Preparation of 2-morpholino-2-phenylacetic acid hydrochloride (139).
Preparation of 2-morpholino-2-phenylacetic acid hydrochloride (139). Ethyl 2-moφholino-2-phenylacetate (0.34 g, 1.36 mmol) was dissolved in dioxane (1 1.4 ml) and 37% HCl (1.1 ml, 13.6 mmol) was added dropwise. The mixture was stirred at reflux overnight. 37% HCl (1.1 ml, 13.6 mmol) was added and the reaction was refluxed for additional 24 h. The solvent was evaporated and the residue was triturated with acetonitrile (10 ml) to obtain 2-moφholino-2-phenylacetic acid hydrochloride (0.22 g, 63.7 % yield) as a white solid. 1H NMR (300 MHz, DMSO-d6) ppm 1 1.79 (s, 1 H), 7.56 - 7.72 (m, 2 H), 7.37 - 7.56 (m, 3 H), 5.25 (s, 1 H), 3.60 - 4.10 (m, 4 H), 3.27 (br. s., 2 H), 2.96 (br. s., 2 H).
References:
WO2013/98145,2013,A1 Location in patent:Page/Page column 50
100609-91-4
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4870-65-9
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37167-62-7
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91641-50-8
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