N- (1- cyano cyclopentyl) pentanaMide synthesis
- Product Name:N- (1- cyano cyclopentyl) pentanaMide
- CAS Number:194984-24-2
- Molecular formula:C11H18N2O
- Molecular Weight:194.27
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Yield:194984-24-2 100%
Reaction Conditions:
with triethylamine in toluene at 20 - 80;
Steps:
1.b
1-Amino-1-cyanocyclopentane (1.10 g) is dissolved in toluene (11 ml), triethytamine (1.5 mi) was added and valeroyl chloride (1.2 ml) was added to this solution dropwise, under cooling at 20°C. After 10-15 min the temperature was raised to 80°C and the mixture was stirred at that temperature for about 2 h. The reaction mixture was then cooled to room temperature and was extracted consecutively with water (5 ml), 2% hydrochloric acid (5 ml) and water (5 ml). The toluene solution was evaporated under vacuo to give N-(1-cyanocyclopentyl)pentanamide (1.94 g, 100%) as white powder. Reference: Bioorg. Med. Chem., 2007, 15, 7391.
References:
EP2194050,2010,A1 Location in patent:Page/Page column 10; 12
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75-34-3
105 suppliers
$22.69/48602
624-24-8
167 suppliers
$16.80/25ML
49830-37-7
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$150.00/250mg
194984-24-2
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109-52-4
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2082-59-9
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