N-(2-tert-butyl-4-bromophenyl)acetamide synthesis
- Product Name:N-(2-tert-butyl-4-bromophenyl)acetamide
- CAS Number:73621-42-8
- Molecular formula:C12H16BrNO
- Molecular Weight:270.17
7402-70-2
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Yield:73621-42-8 100%
Reaction Conditions:
with N-Bromosuccinimide in dichloromethane; for 96 h;
Steps:
5.b
b. Preparation of N-(4-Bromo-2-tert-butylphenyl)acetamide: 45 g (235 mmol) of N-(2-tert-butylphenyl)acetamide are dissolved in 450 ml of dichloromethane. 27.7 g (235 mmol) of N-bromosuccinimide are then added, and the reaction medium is stirred for 48 hours and then filtered. The residue obtained after concentration of the filtrate is dissolved in an ethyl acetate/water mixture and the organic phase is washed with water. The residue obtained is again placed in reaction in the presence of 15 g of N-bromosuccinimide, and then worked up in the same manner after 48 hours. The residue finally obtained is taken up in ethyl acetate, rinsed with sodium thiosulfate solution and then with water, and concentrated under reduced pressure. A pale orange solid is obtained (m=63 g, yield=100%).
References:
US2007/4726,2007,A1 Location in patent:Page/Page column 9
75-36-5
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850012-44-1
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$42.00/100mg
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6310-21-0
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