N-(3-TRIFLUOROMETHYL-PHENYL)-OXALAMIC ACID synthesis
- Product Name:N-(3-TRIFLUOROMETHYL-PHENYL)-OXALAMIC ACID
- CAS Number:6890-83-1
- Molecular formula:C9H6F3NO3
- Molecular Weight:233.14
![ETHYL 2-OXO-2-[3-(TRIFLUOROMETHYL)ANILINO]ACETATE](/StructureFile/ChemBookStructure2/GIF/CB1258213.gif)
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Yield:6890-83-1 87%
Reaction Conditions:
Stage #1: ethyl 2-oxo-2-((3-(trifluoromethyl)phenyl)amino)acetatewith sodium hydroxide;water in ethanol at 45; for 0.75 h;
Stage #2: with hydrogenchloride in ethanol;water; pH=3;
Steps:
132.b
Aqueous 2 N NaOH solution (13 ml, 26 mmol) was added to a solution of ethyl 2-oxo-2-(3-(trifluoromethyl)phenylamino)acetate (2.28 g, 8.74 mmol) in ethanol (23 ml) at 45 °C and stirred at 45 °C for 45 minutes. The reaction was quenched with aqueous 2 N HCl solution (14 ml, pH=3) and concentrated in vacuo. The residue was diluted with H2O (50 ml) and the resulting precipitaion was collected and washed with H2O and n-hexane to give 2-oxo-2-(3-(trifluoromethyl)phenylamino)acetic acid (1.78 g, 87 %) as a white solid.
References:
WO2008/150447,2008,A1 Location in patent:Page/Page column 204
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![2-Mercapto-N-[3-(trifluoromethyl)phenyl]acetamide](/CAS/20140525/GIF/CB22557700.gif)
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![Ethanesulfenyl chloride, 1,1-dichloro-2-oxo-2-[[3-(trifluoromethyl)phenyl]amino]-](/CAS/20210305/GIF/34282-33-2.gif)
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