N-BENZYL 3-BROMOBENZENESULFONAMIDE synthesis
- Product Name:N-BENZYL 3-BROMOBENZENESULFONAMIDE
- CAS Number:625470-36-2
- Molecular formula:C13H12BrNO2S
- Molecular Weight:326.21
22033-09-6
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$240.00/1g
100-46-9
502 suppliers
$5.00/5G
625470-36-2
32 suppliers
$55.00/250mg
Yield:625470-36-2 96%
Reaction Conditions:
with pyridine;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 50; for 2 h;
Steps:
1.1-5.1 (1) Synthesis of 3-bromo-N-benzylbenzenesulfonamide
Take a 100ml single-necked bottle, add 4.74g (0.02mol) of 3-bromobenzenesulfonic acid, and add 100mL of pyridine, stir to dissolve, then add 2.23g (0.024mol) of benzylamine,Then, the condensing agent EDC-HCl 5.73g (0.04mol) was slowly added in batches to the reaction solution, and then heated to 50°C to react for 2h, and the pyridine was removed by rotary evaporation.Pour the remaining water into a separatory funnel, add an appropriate amount of ethyl acetate to extract 3 times, wash the ethyl acetate layer once with dilute hydrochloric acid water, and combine the organic layers,After drying the organic layer over anhydrous sodium sulfate, the solvent was removed under reduced pressure to obtain 6.24 g of white solid in 96% yield.
References:
CN111056979,2020,A Location in patent:Paragraph 0010-0013; 0018-0021
2905-24-0
245 suppliers
$6.00/1g
100-46-9
502 suppliers
$5.00/5G
625470-36-2
32 suppliers
$55.00/250mg
2905-24-0
245 suppliers
$6.00/1g
625470-36-2
32 suppliers
$55.00/250mg