N-BOC-4-METHYL-4-HYDROXY PIPERIDINE synthesis
- Product Name:N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
- CAS Number:406235-30-1
- Molecular formula:C11H21NO3
- Molecular Weight:215.29
676-58-4
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$15.00/25ml
79099-07-3
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$5.00/5g
406235-30-1
120 suppliers
$22.00/250mg
Yield:406235-30-1 99%
Reaction Conditions:
in tetrahydrofuran at -78 - 0; for 2 h;
Steps:
70.A Step A:
tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate
To a solution of tert-butyl 4-oxopiperidine-1-carboxylate (1.00 g, 5.02 mmol) in dry THF (25 mL) was added methylmagnesium chloride (2.17 mL, 6.52 mmol) at -78° C.
The reaction mixture was slowly warmed to 0° C. with stirring for 2 hours and quenched with saturated aq. NH4Cl.
The mixture was extracted with EtOAc twice, and the combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to afford tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (1.08 g, >99%) as a colorless oil, which was used for the next reaction without further purification. 1H-NMR (CDCl3, Varian, 400 MHz): δ 1.27 (3H, s), 1.46 (9H, s), 1.50-1.58 (4H, m), 3.20-3.27 (2H, m), 3.64-3.76 (2H, m).
References:
US2016/168156,2016,A1 Location in patent:Paragraph 0602; 0603
75-16-1
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$12.00/10ml
79099-07-3
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$5.00/5g
406235-30-1
120 suppliers
$22.00/250mg
79099-07-3
0 suppliers
$5.00/5g
406235-30-1
120 suppliers
$22.00/250mg
75-16-1
275 suppliers
$12.00/10ml
109384-19-2
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$5.00/1g
406235-30-1
120 suppliers
$22.00/250mg
917-54-4
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$52.10/25ml
79099-07-3
0 suppliers
$5.00/5g
406235-30-1
120 suppliers
$22.00/250mg