ChemicalBook CAS DataBase List N-BUTYLISOCYANIDE

N-BUTYLISOCYANIDE synthesis

7synthesis methods

Product Name:N-BUTYLISOCYANIDE
CAS Number:2769-64-4
Molecular formula:C5H9N
Molecular Weight:83.13

67-66-3 Synthesis

67-66-3
6 suppliers
$33.60/500ml

109-73-9 Synthesis

109-73-9
439 suppliers
$9.00/1g

2769-64-4
54 suppliers
$45.00/10mg

Yield:-

Reaction Conditions:

with tetra(n-butyl)ammonium hydrogensulfate;sodium hydroxide in dichloromethane;water for 12 h;Inert atmosphere;

Steps:

4.2.1. General procedure for isocyanide synthesis
General procedure: Naphthyl isocyanides and 3-isocyanoquinoline were prepared following literature reported procedures.refPreviewPlaceHolder²⁹ To a well stirred solution of the amine (2.6 mmol) in CH₂Cl₂ (1.5 mL) and CHCl₃ containing n-Bu₄NHSO₄ (90 mg; 0.26 mmol) was added in one portion 50% aqueous NaOH (1.5 mL). The reaction mixture was stirred for 12 h, then diluted with water and extracted with CHCl₃. The combined extracts were dried over MgSO₄ and concentrated in vacuo. Products were purified by column chromatography with DCM as the mobile phase.

References:

Okandeji, Babajide O.;Greenwald, Daniel M.;Wroten, Jessica;Sello, Jason K. [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 24,p. 7679 - 7689] Location in patent:experimental part

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