N-Ethyl 4-MethoxybenzylaMine HCl synthesis

Yield:90389-68-7 83%

Reaction Conditions:

Stage #1: N-ethyl-4-methoxy-benzamidewith bis(cyclopentadienyl)dihydrozirconium;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20; under 760.051 Torr; for 12 h;Inert atmosphere;
Stage #2: with hydrogenchloride in diethyl ether;Inert atmosphere;

Steps:

47

The bis(cyclopentadiene) zirconium dihydride (denoted as Cp2ZrH2, 0.01mmol, 2.23mg), N-ethyl-4-methoxybenzamide (denoted as 3d, 0.2mmol, 35.8mg) and pinna Alcohol borane (denoted as HBpin, 0.6mmol, 87μL), stirred for 12h at room temperature under nitrogen (1atm) atmosphere, treated with hydrogen chloride in ether solution to obtain the hydrochloride compound of formula 4d structure (white solid,N-(4-methoxybenzyl)ethylamine hydrochloride). The isolated yield was 83%.

References:

CN112299938,2021,A Location in patent:Paragraph 0152-0154