N-(Methoxycarbonyl)-L-serine Methyl Ester synthesis
- Product Name:N-(Methoxycarbonyl)-L-serine Methyl Ester
- CAS Number:96854-24-9
- Molecular formula:C6H11NO5
- Molecular Weight:177.16
5680-80-8
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$10.00/5g
79-22-1
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$38.00/1000g
96854-24-9
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$165.00/1g
Yield:96854-24-9 75.39 g (92%)
Reaction Conditions:
with sodium hydroxide in water;
Steps:
1 EXAMPLE 1
EXAMPLE 1 To a solution of 72.03 g L-serine-methylester hydrochloride in 400 ml of water were added at 0° C. 49.5 g of methyl chloroformate. The pH was kept at 6-7 by adding a 40% aqueous solution of sodium hydroxide. After 2 1/2 h at 0° C. the mixture was extracted with 6 portions of ethyl acetate, the combined extracts were dried and evaporated to give 75.39 g (92%) of pure methyl 3-hydroxy-(S)-2-methoxycarbonylamino-propionate. IR (neat): 3380 m (NH, OH), 1720s, br. (C=O), 1535 s (amnide II). MS (El): 178/20 (M+H+).
References:
US6130348,2000,A
2788-84-3
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$367.00/0.25G
79-22-1
2 suppliers
$38.00/1000g
96854-24-9
5 suppliers
$165.00/1g