N,N-dimethyl-2-oxoacetamide synthesis
- Product Name:N,N-dimethyl-2-oxoacetamide
- CAS Number:79036-50-3
- Molecular formula:C4H7NO2
- Molecular Weight:101.1
34640-92-1
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Yield:-
Reaction Conditions:
with hydrogenchloride in water at 57 - 61; for 1.03333 h;Large scale;
Steps:
5 Example 5 Synthesis of 2-[2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylacetamide
A solution of 32% aqueous hydrochloric acid 2.93 kg in water 23.16 kg was heated to 57°C; 2,2-diethoxy-N,N-dimethylacetamide (DEDMA; 5.12 kg (29.23 mol) was added in two minutes to the acidic solution which was then kept under stirring at 58-61°C for 60 min. (DEMDA 5.6% area%). The mixture was cooled to about 20°C, and added with 20% aqueous sodium hydroxide (about 5.48 kg) up to pH 8.8 and concentrated under vacuum at < 45°C to about 29 L residual volume.
References:
NEWRON PHARMACEUTICALS S.P.A.;SKRANC, Wolfgang;WOLBERG, Michael;RIEPL, Matthias;IMBODEN, Christoph;WALDVOGEL, Erwin WO2020/212227, 2020, A1 Location in patent:Page/Page column 12; 8
26549-65-5
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79036-50-3
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996-70-3
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$57.70/1g
79036-50-3
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