N-Nitroso-N-Methyl-4-Aminobutyric Acid synthesis
- Product Name:N-Nitroso-N-Methyl-4-Aminobutyric Acid
- CAS Number:61445-55-4
- Molecular formula:C5H10N2O3
- Molecular Weight:146.14
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Yield:-
Reaction Conditions:
with sodium nitrite at 0; for 1 h;Temperature;
Steps:
1; 2; 3
Add 6.9g (0.1mol) of sodium nitrite to the filtrate, lower the temperature to 0°C, keep stirring and react for 1.0h, raise the temperature to 25°C, use dichloromethane 50g/time, extract twice, combine the dichloromethane phases, and remove the solvent. A light yellow oil is obtained as the target product N-nitroso-N-methyl-4-aminobutyric acid.
References:
Nanjing Hong Sun Pharmaceutical Institute Co., Ltd.;Li Weisi;Shi Lingyun;Gao Qian;Sun Chunxia;Xu Linju;Liu Zhen;Yuan Tao CN112094198, 2020, A Location in patent:Paragraph 0008; 0029; 0031-0032; 0034-0035; 0037