N''-(Prop-2-enoyl)benzohydrazide synthesis
1synthesis methods
- Product Name:N''-(Prop-2-enoyl)benzohydrazide
- CAS Number:10339-47-6
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
Yield:10339-47-6 40%
Reaction Conditions:
Stage #1: benzoic acid hydrazidewith 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 0; for 0.166667 h;Inert atmosphere;
Stage #2: acrylic acid in dichloromethane at 0 - 20;Inert atmosphere;
References:
Milinkevich, Kristin A.;Yoo, Choong L.;Sparks, Thomas C.;Lorsbach, Beth A.;Kurth, Mark J. [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 19,p. 5796 - 5798] Location in patent:supporting information; experimental part