N4-Benzoyl-2'-O-(2-ethoxyethyl)-5-methylcytidine synthesis

Yield:340162-93-8 90%

Reaction Conditions:

with copper(II) nitrate in methanol at 20; for 0.333333 h;

Steps:

General procedure for the deprotection of DMTr-ether and DMPx-ether(Method-B)

General procedure: To a mixture ofDMTr orDMPx-protected nucleosides (1.0mmol) inMeOH(5 mL)was added, triethylsilane (3.0mmol) and 10 mol% of Cu(NO3)2 and stirred the reactionmixture at room temperature for given time (see Table 3). After completion ofthe reaction (monitored by TLC), solvents were distilled out on rotary evaporator toget crude product. The crude compound was purified by column chromatographyusing 60-120 silica gel and (ethyl acetate in hexane) to afford unprotected nucleosides (Table 3).

References:

Penjarla, Srishylam;Prasad, S. Rajendra;Reddy, Dhande Sudhakar;Banerjee, Shyamapada;Penta, Santhosh;Sanghvi, Yogesh S. [Nucleosides, nucleotides and nucleic acids,2018,vol. 37,# 4,p. 232 - 247]