Naphthalene, 1-fluoro-6-methoxy- (9CI) synthesis
- Product Name:Naphthalene, 1-fluoro-6-methoxy- (9CI)
- CAS Number:853192-64-0
- Molecular formula:C11H9FO
- Molecular Weight:176.19
74-88-4
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741693-88-9
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853192-64-0
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Yield:853192-64-0 79%
Reaction Conditions:
with potassium carbonate in acetone at 40; for 15 h;
Steps:
3
Step 3: Iodomethane (866 mg, 381 )lL, 6.1 mmol, Eq: 2) was added to a mixture of 5-fluoronaphthalen-2-ol (494.5 mg, 3.05 mmol, Eq: 1.00) and K2C03 (1.26 g, 9.15 mmol, Eq: 3) inacetone (20 mL) and the mixture heated to 40 °C. After 15 h., the mixture was cooled, diluted with25 EtOAc, washed with H20, dried over Na2S04 and concentrated. The residue was purified by flashchromatography to give 1-fluoro-6-methoxynaphthalene (0.4245 g, 79 %, nearly colorless oil).
References:
WO2014/9495,2014,A1 Location in patent:Page/Page column 62
86-97-5
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853192-64-0
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853192-61-7
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853192-64-0
17 suppliers
$165.00/100mg