Neladenoson dalanate hydrochloride synthesis
- Product Name:Neladenoson dalanate hydrochloride
- CAS Number:1239235-25-6
- Molecular formula:C35H35Cl2N7O4S2
- Molecular Weight:752.73
1239236-11-3
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Yield:1239235-25-6 1.43 g
Reaction Conditions:
with hydrogenchloride in diethyl ether;dichloromethane at 20 - 30;
Steps:
10 Example 10 2-{4-[2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl L-alanyl-L-alaninate hydrochloride-emulation of Example 44 from WO 2010/086101
1.5 g (1.837 mmol) of the protected Boc-dialaninate (VII) were initially charged in 24 ml of dichloromethane. The mixture was briefly heated to reflux, allowed to cool to room temperature and, after addition of 18.37 ml of a IN solution of hydrogen chloride in diethyl ether, stirred at room temperature overnight. The resulting solid was filtered off with suction and washed twice with in each case about 20 ml of diethyl ether. Drying under reduced pressure at 50° C. overnight gave 1.43 g of the target compound.
References:
US2018/155336,2018,A1 Location in patent:Paragraph 0300
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