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Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List NORFLURAZON
27314-13-2

NORFLURAZON synthesis

1synthesis methods
The industrial synthesis of norflurazon begins with the formation of the pyridazinone ring, typically derived from hydrazine and diketone precursors. This heterocyclic core is then functionalized by introducing a trifluoromethyl-substituted aromatic group via nucleophilic substitution or coupling reactions. The methylamino and chloro substituents are introduced through selective halogenation and amination steps, often using reagents like methylamine and phosphorus oxychloride. These reactions are carried out in organic solvents such as acetonitrile or dimethylformamide, under controlled temperature and pH conditions to ensure high yield and regioselectivity.
74-89-5 Synthesis
Methylamine

74-89-5
0 suppliers
$13.44/25ML

26806-47-3 Synthesis
4,5-dichloro-2-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one

26806-47-3
31 suppliers
$33.39/1g

3(2H)-Pyridazinone, 5-chloro-4-(methylamino)-2-[3-(trifluoromethyl)phenyl]-

98796-04-4
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NORFLURAZON

27314-13-2
90 suppliers
$140.00/100mg

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Yield:98796-04-4 27% ，27314-13-2 19%

Reaction Conditions:

in toluene for 7 h;Heating;

References:

Konecny, Vaclav;Kovac, Stefan;Varkonda, Stefan [Collection of Czechoslovak Chemical Communications,1985,vol. 50,# 2,p. 492 - 502]

FullText

NORFLURAZON Related Search:

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