Nornicotine-2-carboxylic Acid synthesis

5synthesis methods

Product Name:Nornicotine-2-carboxylic Acid
CAS Number:3562-11-6
Molecular formula:C10H12N2O2
Molecular Weight:192.21

16518-17-5 Synthesis

16518-17-5
10 suppliers
inquiry

3562-11-6
17 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 5 steps
1: 52 percent / tetrahydrofuran / 20 h / Ambient temperature
2: 95 percent / 0.2 M aq. oxalic acid / 2 h / 90 °C
3: 1.) NH₃, 2.) NH₄Cl / 1.) MeOH, 4 deg C, 30 min, 2.) H₂O, MeOH, RT, 24 h
4: 69 percent / 10percent aq. KOH / 24 h / Heating
5: 67 percent / H₂ / 10percent Pd/C / aq. ethanol / 2 h / 760 Torr

References:

Abbaspour, Aziz;Hecht, Stephen S.;Hoffmann, Dietrich [Journal of Organic Chemistry,1987,vol. 52,# 15,p. 3474 - 3477]

1H-Pyrrole-2-carboxylic acid, 2,3-dihydro-5-(3-pyridinyl)-

71136-44-2
0 suppliers
inquiry

3562-11-6
17 suppliers
inquiry

References

2H-Pyrrole-2-carbonitrile, 3,4-dihydro-5-(3-pyridinyl)-

109065-58-9
0 suppliers
inquiry

3562-11-6
17 suppliers
inquiry

References

2-[3-Oxo-3-(3-pyridyl)propyl]-1,3-dioxolane

109065-57-8
11 suppliers
$110.00/10mg

3562-11-6
17 suppliers
inquiry

References

76014-80-7
16 suppliers
inquiry

3562-11-6
17 suppliers
inquiry

References