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3562-11-6

Nornicotine-2-carboxylic Acid synthesis

5synthesis methods
16518-17-5 Synthesis
POTASSIUM NICOTINATE

16518-17-5
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Yield:-

Steps:

Multi-step reaction with 5 steps
1: 52 percent / tetrahydrofuran / 20 h / Ambient temperature
2: 95 percent / 0.2 M aq. oxalic acid / 2 h / 90 °C
3: 1.) NH3, 2.) NH4Cl / 1.) MeOH, 4 deg C, 30 min, 2.) H2O, MeOH, RT, 24 h
4: 69 percent / 10percent aq. KOH / 24 h / Heating
5: 67 percent / H2 / 10percent Pd/C / aq. ethanol / 2 h / 760 Torr

References:

Abbaspour, Aziz;Hecht, Stephen S.;Hoffmann, Dietrich [Journal of Organic Chemistry,1987,vol. 52,# 15,p. 3474 - 3477]