NSC359875 synthesis
- Product Name:NSC359875
- CAS Number:15263-48-6
- Molecular formula:C10H11NO2
- Molecular Weight:177.2
100-47-0
375 suppliers
$14.14/25gm:
534-03-2
473 suppliers
$7.00/10g
15263-48-6
11 suppliers
inquiry
Yield:15263-48-6 69%
Reaction Conditions:
with anhydrous sodium carbonate in methanol; for 10 h;Reflux;
Steps:
3.1.1. Synthesis of 4a-4h
General procedure: The solution of substituted benzonitrile (100 mmol), serinol (54.660 g, 600 mmol), and Na2CO3 (10.599 g, 100 mmol) in anhydrous methanol (100 mL) was heated to reflux for 10 h. After the reaction solution was cooled to room temperature, the solvent was removed under vacuum, the resulting residue was then diluted with anhydrous CH2Cl2 (30 mL). The organic fractions were successively washed with an aqueous saturated solution of NH4Cl (30 mL 2), brine (30 mL 3), and dried over anhydrous Na2SO4. The solvent was got rid of under vacuum to afford a scarlet residue which was purified by flash column chromatography using petroleum ether/ethyl acetate (8:1, v/v) as the eluent.
References:
Dan, Wenjia;Geng, Huiling;Qiao, Jianwen;Guo, Rui;Wei, Shaopeng;Li, Longbo;Wu, Wenjun;Zhang, Jiwen [Molecules,2016,vol. 21,# 1,art. no. 96]
98-88-4
595 suppliers
$10.00/5g
15263-48-6
11 suppliers
inquiry
825-60-5
9 suppliers
inquiry
15263-48-6
11 suppliers
inquiry