NSC745885 synthesis
- Product Name:NSC745885
- CAS Number:4219-52-7
- Molecular formula:C14H6N2O2S
- Molecular Weight:266.27
1758-68-5
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Yield:4219-52-7 78%
Reaction Conditions:
with pyridine;thionyl chloride in 1,4-dioxane at 70; for 1 h;
Steps:
1 preparation of anthra [1,2-c] [1,2, 5] thiadiazole-6,11-dione
Take 1,2-diamino-anthraquinone (0 · 5g, 2 · lmmol) was dissolved in 1,4-dioxane (10mL), was added thionyl chloride (0. 65mL, 9mmol), was slowly added dropwise pyridine ( 0. 75mL) in dioxane (5mL), 70 ° C for 1 hour. After the reaction, add water (50mL) diluted with ethyl acetate (3 X 50 mL), the organic phases were combined, dried over anhydrous sodium sulfate, then the solvent was evaporated, the residue was purified by silica gel column chromatography (petroleum ether: dichloromethane = 5: 1,1: 1 gradient elution) separation and purification,To give a yellow solid0 ? 44g, yield 78%
References:
CN103319438,2016,B Location in patent:Paragraph 0148-0149
100871-99-6
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