o-Butoxybromobenzene synthesis
- Product Name:o-Butoxybromobenzene
- CAS Number:54514-30-6
- Molecular formula:C10H13BrO
- Molecular Weight:229.11
Yield:54514-30-6 66%
Reaction Conditions:
with sodium hydroxide in water;N,N-dimethyl-formamide at 20; for 4 h;
Steps:
4.3. Synthesis of 2-alkoxybromobenzenes 3-6
General procedure: To a DMF solution (200 ml) of 1 (2.07 g, 12.0 mmol) were added an alkyl iodide (10.8 mmol) and aqueous solution (20 ml) of sodium hydroxide (0.48 g, 12.0 mmol). The mixture was stirred for 4 h at room temperature. After the reaction was completed, the mixture was poured into water (100 ml). The product was extracted with ether (100 ml×3). The extract was dried over anhydrous sodium sulfate. The product was purified by column chromatography (SiO2, C6H14). The physical and spectral data are shown below.
References:
Matsui, Masaki;Shiota, Takahiro;Kubota, Yasuhiro;Funabiki, Kazumasa;Jin, Jiye;Yoshida, Tsukasa;Higashijima, Shinji;Miura, Hidetoshi [Tetrahedron,2012,vol. 68,# 22,p. 4286 - 4291] Location in patent:experimental part
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