O-METHYLBENZYL ACETATE synthesis

14synthesis methods

Product Name:O-METHYLBENZYL ACETATE
CAS Number:17373-93-2
Molecular formula:C10H12O2
Molecular Weight:164.2

89-95-2 Synthesis

89-95-2
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64-19-7 Synthesis

64-19-7
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17373-93-2
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Yield: 98%

Reaction Conditions:

with poly(4-vinylpyridine) perchlorate in neat (no solvent) at 20; for 0.366667 h;

Steps:

2.5 Typical procedure of acetylation
General procedure: The substrate (alcohol, phenol or amine; 1.0 mmol) was treated with Ac₂O (2.0 mmol) in the presence of P(4-VPH)ClO₄ (50 mg) at room temperature under solvent-free conditions and magnetic stirring. After completion of the reaction as indicated by TLC, the mixture was diluted with Et₂O (25 ml) and the catalyst allowed to settle down. The supernatant ethereal solution was decanted off, the catalyst washed with Et₂O (2 ml) and the combined ethereal solution concentrated under vacuum to afford the product, identical(mp, IR, ¹H and ¹³C NMR, and GC-MS) to an authentic sample of acetylated product. The recovered catalyst was dried at 50 °C under vacuum for 2 h. The recovered catalyst, after drying, was reused for four more consecutive acetylation reactions of benzyl alcohol (1.0 mmol) affording 96, 96, 94, and 94% yields, respectively, in 22, 23, 23, and 25 min (Scheme 2).

References:

Khaligh, Nader Ghaffari [Journal of Molecular Catalysis A: Chemical,2012,vol. 363-364,p. 90 - 100]

95-47-6 Synthesis